超脉冲CO2激光联合光动力治疗女性外阴复发性尖锐湿疣的临床疗效

目的 观察超脉冲CO2激光联合5-氨基酮戊酸光动力治疗女性外阴复发性尖锐湿疣(CA)的临床疗效.方法 选取2015年1月至2017年1月在孝感市中心医院皮肤科治疗的120例女性外阴复发性CA患者,按照随机数字表法分为治疗组和对照组,各60例.治疗组接受超脉冲CO2激光联合光动力治疗,对照组仅接受超脉冲CO2激光治疗.两组患者治疗3次结束后,随访6个月,观察两组患者治愈率、再次复发率及治疗后不良反应发生情况.结果 治疗组治愈率为85.00%,水肿发生率为41.67%,均高于对照组,差异有统计学意义(P<0.05);治疗组再次复发率为15.00%,低于对照组,差异有统计学意义(P<0.05).结论 超脉冲CO2激光联合光动力疗法治疗女性外阴复发性CA的治愈率高,再次复发率低,无严重不良反应且患者耐受,值得临床推广应用.

Observation of clinical effectiveness of ultrapulse CO2 laser combined with photodynamic therapy in treatment of recurrent condyloma acuminatum in female vulva

Objective To observe the clinical effectiveness of ultrapulse CO2 laser combined with photodynamic therapy in the treat-ment of recurrent condyloma acuminatum in female vulva.Methods A total of 120 patients were randomly divided into treatment group(n=60)and control group(n=60)by random number table method.The treatment group received CO2 laser combined with photodynamic therapy, while the control group was treated with CO2 laser alone.Followed up for six months after treatment of three times,then the cure rate,recur-rence rate and adverse reactions were evaluated.Results The total effective rate of treatment group was 85%,which was higher than that of control group,the edema in treatment group was 41.67%,which was also higher than that in control group,and there was significant differ-ence between the two groups(P<0.05).The recurrence rate of treatment group was 15%,which was lower than that of control group,and there was significant difference between the two groups(P<0.05).Conclusion Ultrapulse CO2 laser combined with photodynamic therapy in the treatment of female vulvar recurrent condyloma acuminatum has a high cure rate and a low recurrence rate,with no serious adverse re-actionsand good patient tolerance,thus it is worth clinical application.