Pleiotropic effects of polyphenols on glucose and lipid metabolism: Focus on clinical trials |
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| Affiliation: | 1. Liver Center, Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States;2. Department of Biostatistics, University of Washington, Seattle, WA, United States;3. Department of Cardiology, Mount Sinai St. Luke''s Roosevelt Hospital (Bronx-Lebanon Hospital Center), United States;4. Children''s Nutrition Research Center, Baylor College of Medicine, Houston, TX, United States;5. Los Angeles Biomedical Research Institute, Division of Cardiology, Harbor-UCLA Medical Center, Los Angeles, CA, United States |
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| Abstract: | Epidemiological evidence from observational studies suggests that dietary polyphenols (PPs) – phytochemicals found in a variety of plant-based foods – can reduce the risk of developing type 2 diabetes mellitus (T2DM). Clinical trials have also indicated that PPs may help manage the two key features of T2DM, hyperglycemia and dyslipidemia. Since the incidence of T2DM is dramatically increasing worldwide, identifying food-based approaches that can reduce the risk of developing it and help manage its main risk factors in early-stage disease has clinical and socioeconomic relevance.After a brief overview of current epidemiological data on the incidence of T2DM in individuals consuming PP-rich diets, we review the evidence from clinical trials investigating PP-enriched foods and/or PP-based nutraceutical compounds, report their main results, and highlight the knowledge gaps that should be bridged to enhance our understanding of the role of PPs in T2DM development and management. |
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| Keywords: | Polyphenols Type 2 diabetes Dyslipidemia Metabolic syndrome Nutraceutical |
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