| 高氧液对失血性休克家兔循环和血清丙二醛水平的影响 |
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| 引用本文： | 柴伟,孙绪德,高昌俊,张贵和,杨永慧,张晓峰,赵晖,于代华,徐礼鲜. 高氧液对失血性休克家兔循环和血清丙二醛水平的影响[J]. 临床麻醉学杂志, 2004, 20(2): 105-106 |
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| 作者姓名： | 柴伟 孙绪德 高昌俊 张贵和 杨永慧 张晓峰 赵晖 于代华 徐礼鲜 |
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| 作者单位： | 710038,西安市,第四军医大学唐都医院麻醉科;第四军医大学口腔医学院麻醉科 |
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| 基金项目： | 陕西省自然科学基金资助项目 (No .2 0 0 2C2 18) |
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| 摘 要： | 目的 观察高氧液对失血性休克家兔血液动力学的影响。方法 家兔休克90min后回输放血总量1／3的血液,同时分别输注复方乳酸钠(对照组,n=10)及高氧液(治疗组,n=10)。结果 再灌注后治疗组MAP迅速上长,于再灌注后3h显著高于对照组,CVP及HR较快恢复至休克前的水平,而血清丙二醛(MDA)呈下降趋势;对照组再灌注后MDA显著上升,而MAP进行性下降。结论 高氧液能迅速逆转失血性休克血液动力学改变,有效防治休克。
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| 关 键 词： | 高氧液 失血性休克 丙二醛 |
| 修稿时间： | 2003-11-20 |
The effect of hyperoxia saline solution on circulation and serum malondialdehyde of hemorrhagic shock rabbits |
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| Abstract: | Objective To observe the effect of hyperoxia saline solution on reperfusion injury caused by hemorrhagic shock.Methods 20 rabbits were randomly divided into two groups(n=10).90 minutes after hemorrhagic shock artificially,one third volume of the bleeding were perfused,and balanced saline solution(BSS) and hyperoxia BSS were intravenously dripped in group A and group B respectively.MAP,CVP and HR were recorded and MDA evaluated using radioimmunoassay.Result In group B,MAP rose swiftly and became significantly higher at 3 h after reperfusion than that in group A,CVP and HR in group B recovered to the normal level within a short period of time,while serum MDA showed a tendency of decrease.MDA in group A was significantly higher than that in group B.Conclusion Hyperoxia BBS is able to correct the haemodynamic disorder in hemorrhagic shock and has a preventive effect on reperfusion injury. |
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| Keywords: | Hyperoxia saline solution Hemorrhagic shock Malondialdehyde |
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