子宫肌瘤与雌,孕激素及其受体关系的探讨

ESTRADIOL, PROGESTERONE AND THEIR RECEPTORS CONCENTRATIONS IN HUMAN UTERINE LEIOMYOMA

Uterine leiomyomas of thirty-two patients were studied through determinations of E_2R and PR concentrations in cytosol and nucleus of the endometrium, myometrium and myoma tissues of the same uterus by radioreceptorassay. At the same time, estradiol and progesterone of all these tissues in each patient were also measured by radioimmunoassy. The results revealed that the concentrations of E_2R and PR in cytosol and nucleus of tumor cells were in direct proportion to the amount of myoma cells and their nuclear activity. After correction of cytosol receptor for tumor cell count and nuclear receptor for nucleus activity, the concentrations of E_2R and PR in cytosol and nucleus of myoma tissue were found higher than those in the uterine muscular layer of the same uterus (P<0.05). This study demonstrates: (1) receptor concentrations were influenced by degeneration of uterine leiomyoma; (2) variation in receptor concentrations of myoma due to degeneration may be corrected through gradation of cell count and nuclear activity of myoma cells; and (3) the pathogenesis of uterine leiomyoma is possibly related to high local concentrations of E and P as welt as their receptors in the uterus.