Multiple and bilateral kidney tumors with clear cells of three different histotypes: A case report with clinicopathologic and molecular study |
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| Authors: | Maria Rosaria Raspollini Francesca Castiglione Guido Martignoni Alberto Lapini Liang Cheng Rodolfo Montironi Antonio Lopez‐Beltran |
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| Institution: | 1. Histopathology and Molecular Diagnostics, Universital Hospital Careggi, Florence, Italy;2. Anatomic Pathology, Department of Pathology, University of Verona, Verona, Italy;3. Department of Urology, Universital Hospital Careggi, Florence, Italy;4. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA;5. Section of Pathological Anatomy, Department of Biomedical Sciences and Public Health, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy;6. Unit of Anatomic Pathology, Department of Surgery, Cordoba University Medical School, Cordoba, Spain;7. Champalimaud Clinical Center, Lisbon, Portugal |
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| Abstract: | We describe a rare multicentric neoplastic disease arising bilteraly in the kidney. The patient was a 70‐year‐old man, who, during a period of 3 years, was treated for five independent tumors of three histotypes (three multilocular cystic clear cell renal cell neoplasms of low malignant potential, one clear cell renal cell carcinoma, and one clear cell papillary renal cell carcinoma, respectively). Pathologic diagnosis of the reported tumors was confirmed by immunohistochemical analyses, including CD10, CA IX, CK7, AMACR/RACEMASE, and 34 beta E12. Molecular detection of KRAS, BRAF, NRAS, PIK3CA, ALK, ERBB2, DDR2, MAP2K1, RET, and EGFR gene mutational analysis was also performed in all tumors. |
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| Keywords: | Clear cell renal cell carcinoma multilocular cystic clear cell renal cell neoplasm of low malignant potential clear cell papillary renal cell carcinoma
KRAS
NRAS
BRAF
PIK3CA
ALK
ERBB2
DDR2
MAP2K1
RET
EGFR
kidney molecular pathology |
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