艰难梭状芽胞杆菌感染的危险因素分析

目的 探讨艰难梭状芽胞杆菌感染的高危易感因素,为提高艰难梭状芽胞杆菌感染评估能力提供参考依据.方法 选取2018年5月至2020年3月于四川大学华西医院住院接受治疗的296例患者为研究对象,其中临床表现为腹泻且粪便中艰难梭状芽胞杆菌阳性的134例住院患者作为感染组;同期明确为无艰难梭状芽胞杆菌感染的住院患者162例作为...

Analysis of related factors of Clostridium difficile infection

Objective To explore the high risk factors of Clostridium difficile, and to provide reference for improving the ability to evaluate the Clostridium difficile infection.Methods A total of 296 patients who were hospitalized in West China Hospital of Sichuan University from May 2018 to March 2020 were selected as the study objects, among whom 134 patients with diarrhea and positive fecal Clostridium difficile were selected as the infection group;at the same time, 162 hospitalized patients without Clostridium difficile infection were selected as the control group. The general clinical data of patients were collected and sorted out;the levels of creatinine, alanine aminotransferase and albumin were measured by automatic biochemical analyzer,andthe leukocyte count was detected by automatic blood analyzer. In addition, single factor and multi factor Logistic regression analyses were used to analyze the factors influencing the infection of Clostridium difficile.Results There was no significant difference between the two groups in gender, age, residence, serum creatinine, alanine aminotransferase, chronic kidney disease, blood disease and metabolic disease (P>0.05);theleukocyte count, proportions of fever, non-alcoholic fatty liver disease, respiratory system disease, cardiovascular disease, gastrointestinal disease, malignant tumor, history of intensive care, chemotherapy, quinolones use, carbapenems use, gastric acid inhibitor use, cephalosporin use in infection group were higher than those in control group, the level of albumin was lower than that in control group, and the differences were all statistically significant (P<0.05);single factor Logistic regression analysis showed that fever, nonalcoholic fatty liver disease, cardiovascular disease and quinolones were the risk factors of Clostridium difficile infection (P<0.05); in addition, multivariate Logistic regression analysis showed that nonalcoholic fatty liver disease and quinolones were the independent risk factors of Clostridium difficile infection (P<0.05).Conclusions Nonalcoholic fatty liver disease is a predisposing factor of Clostridium difficile infection as detected in our hospital, which may have a high reference value for clinical prevention of Clostridium difficile infection.