Expression and significance of HIF-1α and ET-1 in gastrointestinal stromal tumors |
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引用本文: | 艾晓辉,廖国庆,刘合利,刘湘国,周林刚,刘阳志,刘安文.Expression and significance of HIF-1α and ET-1 in gastrointestinal stromal tumors[J].中华实验外科杂志,2009,26(1):890-891. |
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作者姓名: | 艾晓辉 廖国庆 刘合利 刘湘国 周林刚 刘阳志 刘安文 |
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作者单位: | 湖南省邵阳市中医院肿瘤普外科,422001;中南大学湘雅医院胃肠外科,长沙,410008; |
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基金项目: | 湖南省卫生厅基金资助项目湖南省自然科学基金资助项目 |
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摘 要: | Objective To explore the expression and the value of HIF-1α,and ET-1 in judging the prognosis of gastrointestinal stromal tumors (GISTs). Methods The expression of HIF-1α, and ET-1 protein was examined in 76 GISTs by immunohistochemistry S -P methods. Results There was a positive correlation between the expression of HIF-1 α and ET-1 ( P < 0.05 ). The positive expression rate of HIF-1 α and ET-1 was 73.68% (50/76) ,and 65.79% (50/76) respectively,which was related with histologicial grade, tumor diameter, infiltration and metastasis, nuclear division rating of GISTs ( P < 0.05 ), but had no relationship with patients' age, gender, initial position of the tumor ( P > 0.05 ). There was statistically sig-nificant difference in the expression of HIF-1 α and ET-1 in the following groups:among the three classes of very low-risk and low-risk, middle-risk, high-risk, bewteen the diameter < 2 cm and > 5 cm (P < 0.05). The more malignant degree and larger diameter, the more highly positive expression rate ( P < 0.05 ). The positive expression in the groups with infiltration and metastasis, and nuclear division ≥5/50 HP was sig-nificantly higher than the groups without infiltration and metastasis, and nuclear division < 5/50 HP (P < 0.05). Conclusion The expression of HIF-1α had a significant correlation with ET-1. HIF-1α,and ET-1 expression was closely related with the prognosis of GISTs,and can serve as important predictors for survival.
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关 键 词: | 胃肠道间质瘤 缺氧诱导因子 内皮素-1 免疫组织化学 Hypoxia inducible factor 1 α |
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