食管贲门重复癌及重复高级别上皮内瘤变患病队列分析

 目的从经典的重复癌诊断和WHO肿瘤新分类两个标准，分析食管癌高发区食管贲门重复癌和重复高级别上皮内瘤变患病情况。方法选择河北省磁县2013例40-69岁队列人群为样本。根据WHO新分类标准，将食管鳞状上皮的重度不典型增生、原位癌和贲门腺上皮重度不典型增生、粘膜内癌划为高级别上皮内瘤变（HIN）。对食管和贲门病理同时为HIN的作为重复HIN诊断；食管贲门重复癌仍采用Warren标准。结果以Warren的诊断标准统计，食管贲门重复癌患病率为0．01％（2／2013），占食管贲门原位癌、粘膜内癌和早期浸润癌总检出的2．2％（2／88）；重复HIN患病率0．2％（4／2013），占HIN总检出的3．3％（4／123）。结论磁县40-65岁人群食管贲门重复癌和重复HIN患病率相对较高。

The Esophagus with Cardia Multiplecarcinoma and Multiple High Grade Intraepithelial Neoplasia in Cohort Study

Objective 　According to the diagnosis of classical supercarcinoma and the criterion of the WHO pathology of new classify of tumours in 2000 years ,which is high grade int raepithelial neoplasia ( HIN) , to investigate prevalence condition for multiplecarcinoma and HIN in the area of high incidence of esopha2 geal carcinoma. Methods 　Two thousand and thirteen persons with 40～69 age and through endoscopic examination were enrolled in cohort study ,depending on the criterion of the WHO pathology of new clas2 sify of tumours ,severe dysplasia ,carcinoma2in2situ for esophageal sequmous cell and severe dysplasia ,in2 t ramucosal cancer for cardia adeno2epithelia cell were classiified as high2grade int raepithelia neoplasia ( HIN) . For pathology at the same time were HIN in esophagus with cardia as multiple2HIN diagnosis , still Warren standard was adopted for esophagus with cardia multiplecarcinamo ( ECM) . Results 　Preva2 lence rate was 0. 01 % for ECM ,it occupied 2. 2 % on total detecting carcinoma2in2situ ,int ramucosal canc2 er and early invasive carcinoma ,multiple $ HIN was 0. 2 % ,that account for 3. 3 % in all HIN. Conclusion Forty～Sixty2five years old crowd in Ci2county ,prevalence rate were relatively higher for ECM and multi2 ple2HIN.