| 绞股蓝总皂甙对离体大鼠肝脏脂质过氧化及膜流动性损伤的保护作用 |
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| 引用本文： | 李林,邢善田,周金黄. 绞股蓝总皂甙对离体大鼠肝脏脂质过氧化及膜流动性损伤的保护作用[J]. 中国药理学通报, 1991, 0(5) |
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| 作者姓名： | 李林 邢善田 周金黄 |
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| 作者单位： | 北京老年病医疗研究中心 100053(李林)，军事医学科学院毒物药物研究所 北京100850(邢善田)，军事医学科学院毒物药物研究所 北京100850(周金黄) |
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| 摘 要： | 在体外实验中绞股篮总皂甙(GP)能抑制大鼠肝微粒体自发的和由Fe_-~(2+)-半胱氨酸、Vit C-NADPH和CCl_4诱发的脂质过氧化,其作用强于人参总皂甙。Fe_-~(2+)-半胱氨酸导致大鼠肝微粒体、线粒体膜流动性降低,同时加入GP可防止膜流动性的下降。
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| 关 键 词： | 绞股蓝总皂甙 肝脏 脂质过氧化 膜流动性 |
PROTECTIVE EFFECTS OF GYPENOSIDES ON RAT HEPATIC LIPID PEROXIDATION AND MEMBRANE FLUIDITY DAMAGE: IN VITRO STUDIES |
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| Li Lin,Xing Shantian,Zhou Jinhuang. PROTECTIVE EFFECTS OF GYPENOSIDES ON RAT HEPATIC LIPID PEROXIDATION AND MEMBRANE FLUIDITY DAMAGE: IN VITRO STUDIES[J]. Chinese Pharmacological Bulletin, 1991, 0(5) |
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| Authors: | Li Lin Xing Shantian Zhou Jinhuang |
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| Affiliation: | Li Lin1,Xing Shantian,Zhou Jinhuang |
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| Abstract: | The present in vitro study on rat liver microsomal lipid per-oxidation showed that Gypenosides ( GP ) , the total saponin of Gy-nostemma pentaphyllum Makino, produced a marked inhibitory effect on the lipid peroxidation either spontaneously or induced by Fe2 -cystein, Vit C-NADPH and CCl4. The inhibitory effect was found to be stronger than that of Ginsenosides. GP also resisted the decrease of fluidity of liver microsomal and mitochondrial membrane induced by Fe2 -cystein. |
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| Keywords: | Gypenoside Liver Lipid peroxidation Membrane fluidity |
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