活血解毒中药配伍干预介入后不稳定型心绞痛的临床研究

目的探讨在常规西医治疗的基础上加用活血解毒中药对不稳定型心绞痛的治疗效果，观察治疗前后不稳定型心绞痛患者中医主症计分、血瘀证计分、心绞痛计分、高敏C反应蛋白（hs—CRP）和血脂等指标的变化。方法将介入治疗后不稳定型心绞痛患者61例随机分为活血解毒组（30例）与活血组（31例）。两组均服药两周，两周后对治疗前后中医主症计分、血瘀证计分、心绞痛计分、实验室指标、治疗前后心电图进行观察；以后每3个月门诊或电话随访1次，随访6个月，重点观察生存质量、终点指标发生的情况。结果活血解毒组治疗后可显著降低冠心病不稳定型心绞痛患者的hs～CRP水平，而活血组治疗后效果不显著（P〉0．05）。与活血组相比，活血解毒组有进一步降低不稳定型心绞痛患者心绞痛计分的作用趋势。结论在西医常规治疗基础上加用活血解毒药物可降低介入后不稳定型心绞痛患者的hs—CRP水平，改善心绞痛症状。

Clinical Study of Unstable Angina Patients Undergoing Percutaneous Coronary Intervention Treated with Chinese Medicine for Activating Blood Circulation and Detoxicating

Objective To evaluate the effects on unstable angina（OA） undergoing percutaneous coronary intervention（PCI）treated wyth Chinese medicine for activating blood circulation and detoxicating. Methods Sixty - one patients diagnosed by UA and treated by PCI and conventional medicine were randomly divided into two groups：Treatment group（n= 30） treated with traditional Chinese medicine for activating blood circulation and detoxicating,control group（n= 31） treated with traditional Chinese medicine for activating blood circulation for two weeks. The score of traditional Chinese rnedicine（TCM）primary symptoms, blood stasis syndrome,an- gina integral, the result of laboratory examination, electrocardiogram（ECG）were observed pre - treatment and post - treatment. Results The level of high - sensitivity C - reactive protein（hs - CRP） in treatment group decreased markedly after treatment. There was no statistical significance in the level of hs -CRP in control group between pretreatment and post- treatment（P〉0.05）. Compared with the control group,the treatment group seemed to show superiority in lowering the angina integral of UA. Conclusion Routine western medical treatment combined with activating blood circulation and detoxicating drugs could decrease the level of hs - CRP and alleviate clinical symptoms in UA patients undergoing PCI.