| 不同光照对盐酸左氧氟沙星注射液稳定性的影响 |
| |
| 引用本文： | 陈金月,文隽,龚敏阳,梁丽英.不同光照对盐酸左氧氟沙星注射液稳定性的影响[J].中国药房,2005,16(6):459-460. |
| |
| 作者姓名： | 陈金月 文隽 龚敏阳 梁丽英 |
| |
| 作者单位： | 广西中医学院附属第一医院药剂科,南宁市,530023 |
| |
| 摘 要： | 目的 :探讨不同光源照射对盐酸左氧氟沙星注射液稳定性的影响程度。方法 :分别选择紫外光、太阳光、自然光作为照射光源 ,观察盐酸左氧氟沙星注射液在3种光源下照射不同时间后的光谱变化并测定其含量 ,另用薄层色谱法检查有无分解产物生成。结果 :盐酸左氧氟沙星注射液在3种光照下均有分解 ,以太阳光照射下分解最快 ;以薄层色谱法检查出降解产物的Rf值为0 .72。结论 :盐酸左氧氟沙星注射液应避开紫外光、太阳光、自然光保存。
|
| 关 键 词： | 盐酸左氧氟沙星注射液 光照射 稳定性 薄层色谱法 |
| 文章编号： | 1001-0408(2005)06-0459-02 |
| 修稿时间： | 2004年6月16日 |
Experiment of the Photostability of the Levofloxacin Hydrochloride Injection |
| |
| CHEN Jinyue,Wen Juan,GONG Minyang,LIANG Liying.Experiment of the Photostability of the Levofloxacin Hydrochloride Injection[J].China Pharmacy,2005,16(6):459-460. |
| |
| Authors: | CHEN Jinyue Wen Juan GONG Minyang LIANG Liying |
| |
| Abstract: | OBJECTIVE: To study the photostability of the levofloxacin hydrochloride injection. METHODS: The content of levofloxacin hydrochloride was determined and its UV spectra changes were observed after being lighted by three different light sources-the UV light, the sunlight and the natural light for different periods of time. Whether there is any decomposed product or not was determined by TLC. RESULTS: There were decompositions of levofloxacin hydrochloride injection subjected to illumination from three light resources, with that under the sunlight decomposed faster; Rf value under TLC of the decomposed product was found to be 0.72. CONCLUSION: Levofloxacin hydrochloride injection should be kept away from UV light, the sunlight and the natural light. |
| |
| Keywords: | Levofloxacin hydrochloride injection Light illumination Stability TLC |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
