Linkage disequilibria between HLA-B and the rarer properdin factor B alleles, BfF1 and BfS1期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Linkage disequilibria between HLA-B and the rarer properdin factor B alleles, Bf^F1 and Bf^S1

Authors:	G.J. Stewart H.M. Cann F.C. Grumet R. Hay R.L. Kirk R. Payne

Affiliation:	1. Department of Medicine, Pediatrics, Genetics, and Pathology, Stanford University School of Medicine, Stanford, California, USA;2. South Australian Red Cross Blood Transfusion Service, Adelaide, Australia;3. Department of Human Biology, John Curtin School of Medical Research, Canberra, Australia

Abstract:	Phenotypic association and highly significant linkage disequilibria have been demonstrated for HLA-B18 and Bf^F1 and HLA-Bw50 and Bf^S1 alleles among Caucasians from Australia and the United States (San Francisco Bay area). The HLA-B18, Bf^uF1 association appears to be associated with HLA-Aw30. It is possible that Bf^S1 as a mutation, after the evolutionary splitting of HLA-Bw21, on an HLA-Bw50 haplotype, and that Bf^F1 arose on an HLA-Aw30, B18 haplotype.

Keywords:	Bf properdin factor B IDDM insulin dependent diabetes mellitus LD linkage disequilibrium
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