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Role of omega-3 ethyl ester concentrate in reducing sudden cardiac death following myocardial infarction and in management of hypertriglyceridemia: An Indian consensus statement |
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| Authors: | J.J. Dalal R.R. Kasliwal A.L. Dutta J.P.S. Sawhney S.S. Iyengar S. Dani N. Desai I. Sathyamurthy D. Rao A. Menon A. Dasbiswas G.S. Wander M. Chadha M.S. Hiremath D.G. Roy V. Gupta N. Shivakadaksham |
| Affiliation: | 1. Director, Cardiac Sciences, Kokilaben Dhirubhai Ambani Hospital, Mumbai 400053, India;2. Chairman, Department of Clinical and Preventive Cardiology, Medanta-The Medicity, Gurgaon, India;3. HOD, Cardiology, Peerless Hospital, Kolkata, India;4. Chairman, Department of Cardiology, Sir Gangaram Hospital, New Delhi, India;5. HOD, Cardiology, Manipal Hospital, Bangalore, India;6. Director, Cardiology, Apollo Hospital, Ahmedabad, India;7. Chief Cardiologist, Vagus Hospital, Bangalore, India;8. HOD, Cardiology, Apollo Hospital, Chennai, India;9. Sr. Consultant Cardiologist, KIMS Hospital, Hyderabad, India;10. Sr. Consultant Cardiologist, Lilavati Hospital, Mumbai, India;11. Director, Institute of Cardiovascular Sciences, IPGME&R, Kolkata, India;12. Prof and HOD of Cardiology, IPGME&R, Kolkata, India;13. Chief Cardiologist, Hero DMC Heart Institute, Ludhiana, India;14. Department of Endocrinology, P D Hinduja Hospital, Mumbai, India;15. Director, Cath Lab, Ruby Hospital, Pune, India;p. Sr. Consultant Cardiologist, Peerless Hospital, Kolkata, India;q. Sr. Consultant Cardiologist, Indraprastha Apollo Hospital, New Delhi, India;r. Sr. Consultant Cardiologist, Chennai, India |
| Abstract: | IntroductionSudden cardiac death (SCD) is the most lethal manifestation of heart disease. In an Indian study the SCDs contribute about 10% of the total mortality and SCD post ST elevation myocardial infarction (MI) constitutes for about half of total deaths.ObjectiveGiven the limitations of existing therapy there is a need for an effective, easy to use, broadly applicable and affordable intervention to prevent SCD post MI. Leading cardiologists from all over India came together to discuss the potential role of n-3 acid ethyl esters (90%) of eicosapentaenoic acid (EPA) 460 mg & docosahexaenoic acid (DHA) 380 mg in the management of post MI patients and those with hypertriglyceridemia.RecommendationsHighly purified & concentrated omega-3 ethyl esters (90%) of EPA (460 mg) & DHA (380 mg) has clinically proven benefits in improving post MI outcomes (significant 15% risk reduction for all-cause mortality, 20% risk reduction for CVD and 45% risk reduction in SCD in GISSI-Prevenzione trial) and in reducing hypertriglyceridemia, and hence, represent an interesting option adding to the treatment armamentarium in the secondary prevention after MI based on its anti-arrhythmogenic effects and also in reducing hypertriglyceridemia. |
| Keywords: | Sudden cardiac death Myocardial infarction Hypertriglyceridemia Omega-3-acid ethyl esters Eicosapentaenoic acid & docosahexaenoic acid |
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