| 钙敏感受体在心血管生理和疾病中的作用 |
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| 引用本文： | 熊春明,张朝颖. 钙敏感受体在心血管生理和疾病中的作用[J]. 心脏杂志, 2019, 31(3): 343-346. DOI: 10.12125/j.chj.201809003 |
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| 作者姓名： | 熊春明 张朝颖 |
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| 作者单位： | 1.研究生院 |
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| 基金项目： | 黑龙江省教育厅科学技术研究项目资助（12511298） |
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| 摘 要： | 钙敏感受体(calcium sensing receptor，CaSR)是G蛋白偶联受体(GPCRs)C家族成员之一，能被Ca2+、Mg2+、氨基酸、多胺等激活，它是公认的具有广泛表达功能的受体，在甲状旁腺、肾脏、肠道、骨骼系统高度表达，也在心血管系统的不同组织中表达，发挥不同作用，从而参与心血管系统的生理病理过程。本综述是概述CaSR对心血管系统的重要性。
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| 关 键 词： | 钙敏感受体 内皮细胞 血管平滑肌细胞 心肌细胞 |
| 收稿时间： | 2018-09-04 |
Role of calcium sensing receptors in cardiovascular physiology and disease |
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| Affiliation: | 1.Graduate School Graduate School2.Department of Cardiology, Fourth Affiliated Hospital, Harbin Medical University, Harbin150001, Heilongjiang, China |
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| Abstract: | Calcium sensing receptor (CaSR), a member of the G protein coupled receptor (GPCRs) C family, can be activated by Ca2+ Mg2+, amino acids, and polyamines. It is now recognized as an ubiquitously expressed receptor and is highly expressed in the parathyroid gland, kidneys, intestinal system, and skeletal system. It also plays different roles in different tissues of the cardiovascular system and participates in physiological and pathological processes of the cardiovascular system. The focus of this review is to summarize the importance of CaSR in the cardiovascular system. |
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