纤维蛋白原含量与分泌性中耳炎病情迁延的关系

目的:探讨中耳积液中纤维蛋白原含量与分泌性中耳炎病情迁延的关系。方法:用凝固法对98例成人患者中耳积液中纤维蛋白原进行动态检测。结果:98例患者经鼓膜穿刺治疗后62例未愈,治愈组和迁延组纤维蛋白原检测阳性率分别为30.56%和72.58%,P<0.01;浓度分别为(0.350±0.124)g/L和(0.568±0.206)g/L,P<0.05。迁延组中52例患者第2次穿刺治疗中耳积液中纤维蛋白原浓度为(1.241±0.146)g/L,明显高于第1次[(0.685±0.251)g/L],P<0.01。结论:纤维蛋白原含量与分泌性中耳炎病情迁延密切相关,可能在粘连性中耳炎形成中起重要作用。

Relationship between fibrinogen content and the protracted inflammation of secretory otitis media

OBJECTIVE: To study the relationship between fibrinogen content and the protracted inflammation of secretory otitis media(SOM). METHOD: The fibrinogen content of 98 patients with SOM was monitored with von-clauss technique at different stages. RESULT: Sixty-two patients of 98 patients with SOM experiences were not cured after the treatment by myringopuncture. The positive rate and the concentration of fibrinogen in the protracted group were 72.58% and (0.568 +/- 0.206) g/L respectively, higher than those in the cured group, 30. 56% and (0.350 +/- 0.124) g/L ( P < 0.05 in all ); fifty-two of sixty-two patients in protracted group were not cured after the second treatment of myringopuncture, the concentration of fibrinogen in the second protracted group were (1.241 +/- 0.146) g/L, higher than that in the first protracted group,(0.685 +/- 0.251) g/L (P < 0.01). CONCLUSION: Fibrinogen content has significant relationship with the protracted inflammation of SOM. It might play an important role in the pathological course of middle ear adhesions.