Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy |
| |
| Authors: | Lutz Hamann Oliver Kumpf Ron P Schuring Erkan Alpsoy George Bedu-Addo Ulrich Bienzle Linda Oskam Frank P Mockenhaupt Ralf R Schumann |
| |
| Affiliation: | (1) Institute of Medical Microbiology and Hygiene, Charit? – University Medical Center, Berlin, Germany;(2) Institute of Tropical Medicine and International Health, Charit? – University Medical Center, Berlin, Germany;(3) Department of Surgery and Surgical Oncology, Robert-R?ssle-Klinik, Charit? – University Medical Center, Berlin, Germany;(4) KIT (Royal Tropical Institute) Biomedical Research, Amsterdam, The Netherlands;(5) Department of Dermatology and Venerology, Akdeniz University School of Medicine, Antalya, Turkey;(6) Komfo Anoyke Teaching Hospital, School of Medical Sciences, University of Science and Technology, Kumasi, Ghana |
| |
| Abstract: | ![]()
Background The Toll-like receptors (TLRs) mediate innate immunity to various pathogens. A mutation (S180L) in the TLR downstream signal transducer TIRAP has recently been reported to be common in Europeans and Africans and to roughly half the risks of heterogeneous infectious diseases including malaria, tuberculosis, bacteremia, and invasive pneumococal disease in heterozygous mutation carriers. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
