冠心病患者血脂相关指标与冠状动脉狭窄的相关性分析

目的 评估血脂相关指标对冠心病患者冠状动脉狭窄病情评估的临床价值。方法 回顾性纳入422名行冠状动脉造影检查的患者，记录相关实验室检查数据。根据冠脉狭窄程度分位冠状动脉狭窄程度<50%组和≥50%组，根据Gensini评分分为G1组(积分<4),G2组(积分4～20),G3组(积分21～32),G4组(积分>32)四组。血脂相关指标进行组间比较和与Gensini积分的相关性分析。结果 冠脉狭窄程度不同的两组患者血清总胆固醇(TC)、三酰甘油(TG)、三酰甘油葡萄糖指数(TyG指数)、低密度脂蛋白胆固醇(LDL-C)、残余胆固醇(RC)、非高密度脂蛋白胆固醇(non-HDL-C)、小而密低密度脂蛋白胆固醇(sd-LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平差异均具有统计学意义(P<0.05)。血清脂蛋白a[Lp(a)]水平差异无统计学意义。Gensini积分进行分组比较，发现血清TC、TG、non-HDL-C和sd-LDL-C水平，G4组显著高于G3组，G3组显著高于G2组，G2组显著高于G1组。G4组血清LDL-C水平显著高于G3组，TyG指数和RC水平，...

The Relationship Between Blood Lipid-Related Indexes and Severity of Coronary Artery Stenosis

Objective To evaluate the clinical value of lipid related indexes in the evaluation of the severity of coronary artery stenosis in coronary heart disease patients.Methods 422 patients undergoing coronary angiography were enrolled retrospectively and patients’laboratory tests results were collected.According to the degree of coronary artery stenosis,the groups of coronary artery stenosis<50%and coronary artery stenosis≥50%were classified among patients.All patients were divided into 4 groups according to Gensini score:G1(<4),G2(4-20),G3(21-32)and G4(>32).Laboratory tests results were compared among groups and correlations with Gensini were analyzed.Results TC,TG,TyG index,LDL-C,RC,non-HDL-C and sd-LDL-C levels were higher in the coronary artery stenosis≥50%group than the coronary artery stenosis<50%group(P<0.05),while HDL-C was lower(P<0.05).Lp(a)had no significant difference between them(P>0.05).Levels of TC,TG,non-HDL-C and sd-LDL-C in G4 group were significantly higher than those in G3 group,while G3 group was significantly higher than G2 group,and G2 group was significantly higher than G1 group.LDL-C level in G4 group was significantly higher than that in G3 group,while TyG index and RC levels in G3 group were significantly higher than those in G2 group,and G2 group was significantly higher than G1 group,with statistical significance(P<0.05).Except for Lp(a),all other indicators were statistically correlated with Gensini Score(P<0.05).Conclusion Monitoring of blood lipid-related indexes has a clinical comprehensive evaluation and therapeutic guidance value for coronary artery stenosis patients.