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| UPLC-MS/MS检测减肥类保健食品中的西布曲明及其去甲基衍生物 | |
| 引用本文： | 沈国芳,朱建,裘一婧. UPLC-MS/MS检测减肥类保健食品中的西布曲明及其去甲基衍生物[J]. 中国药学杂志, 2011, 46(20): 1609-1611 |
| 作者姓名： | 沈国芳 朱建 裘一婧 |
| 作者单位： | 杭州市药品检验所; |
| 摘 要： | 目的 建立减肥类保健食品中非法添加化学成分西布曲明、N-单去甲基西布曲明和N,N-双去甲基西布曲明的UPLC-MS/MS定性检测方法。方法 以甲醇超声提取样品，UPLC进行色谱分析，采用串联四级杆质谱进行定性检测。结果 西布曲明、N-单去甲基西布曲明和N,N-双去甲基西布曲明保留时间分别为1.29、0.97和0.92 min，65批样品中21批检出西布曲明，1批检出N-单去甲基西布曲明，1批检出N,N-双去甲基西布曲明。结论 本方法专属性强，操作简单，快捷，可作为掺入西布曲明及其去甲基衍生物的保健食品有效检测方法。 |
| 关 键 词： | 超高效液相色谱-质谱联用法 西布曲明 |
| 收稿时间： | 2011-11-11; |
UPLC-MS/MS Method for Determination of Sibutramine and Its Desmethyl Derivatives Added in Slimming Foods |
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| SHEN Guo-fang,ZHU Jian,Qiu Yi-jing. UPLC-MS/MS Method for Determination of Sibutramine and Its Desmethyl Derivatives Added in Slimming Foods[J]. Chinese Pharmaceutical Journal, 2011, 46(20): 1609-1611 | |
| Authors: | SHEN Guo-fang ZHU Jian Qiu Yi-jing |
| Affiliation: | SHEN Guo-fang,ZHU Jian,Qiu Yi-jing(Hangzhou Institute for Drug Control,Hangzhou 310017,China) |
| Abstract: | OBJECTIVE To develop a UPLC-MS/MS method to determine the illegal addition of sibutramine,N-desmethyl sibutramine and N,N-di-desmethyl sibutramine in slimming foods.METHODS The sample was extracted with methanol by ultrasonic processing,separated by quick UPLC,and detected by quadrupole mass spectrometry with daughters scan mode.RESULTS The retention times of sibutramine,N-desmethyl sibutramine and N,N-di-desmethyl sibutramine were 1.29,0.97 and 0.92 min,respectively.Twenty-one samples of all 65 slimming fo... |
| Keywords: | UPLC-MS/MS sibutramine desmethyl |
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