思诺思对失眠症患者QUISI检测指标的影响

目的 应用QUISI仪检测思诺思对失眠症患者睡眠脑电活动的影响。方法 对32例失眠症患者进行连续3夜的QUISI描记，其中第3晚睡前30 min给予10 mg思诺思，观察用药后QUISI指标的变化。另设正常对照者28名，进行1夜适应和1夜基础QUISI监测。结果 失眠症组患者服用思诺思前夜间QUISI检测指标与正常对照组比较差异均有统计学意义（P<0.05或P<0.01）。失眠症组患者服用思诺思后，夜间QUISI检测显示睡眠效率提高，服药前和服药后睡眠效率为（87.7±7.3）% vs（91.4±3.8）%；醒觉时间为（40.5±15.5）min vs（22.1±6.1）min；S1为（29.9±18.3）％ vs （16.1±6.5）％；S2为（43.9±17.3）％ vs（59.1±4.7）％；睡眠潜伏期为（35.7±17.0）min vs（21.1±11.0）min（P<0.05或P<0.01）。结论 思诺思不仅能改善患者对睡眠的主观评价，还对夜间睡眠脑电有影响。

Effects of Stilnox on QUISI parameters in patients with insomnia

Objective To investigate the effects of Stilnox on brain electrical activity in patients with insomnia using QUISI sleep instrument. Methods QUISI sleep instrument was employed  for 32 patients with insomnia for 3 consecutive nights, among whom 10 mg Stilnox was administrated before sleep on the third night, and the changes of AUISI parameters were observed after Stilnox administration. Another 28 normal controls were selected, and received one night of acclimatization and the other night of baseline QUISI monitoring. Results There were significant differences in QUISI parameters between patients with insomnia and normal controls before Stilnox administration (P<0.05 or P<0.01). Compared with those before Stilnox administration, patients with insomnia had improved sleep efficiency [(87.7±7.3%)% vs (91.4±3.8)%], reduced awake time [(40.5±15.5) min vs (22.1±6.1) min], reduced S1 [(29.9±18.3)% vs （16.1±6.5）%], increased S2 [(43.9±17.3)% vs (59.1±4.7)%] and shortened sleep latency [(35.7±17.0)min vs （21.1±11.0）min] after Stilnox administration(P<0.05 or P<0.01). Conclusion Stilnox not only can improve the subjective evaluation on sleep, but also have effects on brain electrical activity in night in patients with insomnia.