Renal protection by 3H-1,2-dithiole-3-thione against cisplatin through the Nrf2-antioxidant pathway |
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| Authors: | Park Hyun-Min Cho Jeong-Min Lee Hyang-Rim Shim Gi-seoung Kwak Mi-Kyoung |
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| Affiliation: | Yeungnam University, College of Pharmacy, 214-1 Dae-dong, Gyeongsan-si, Gyeongsangbuk-do 712-749, South Korea. |
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| Abstract: | ![]()
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| Keywords: | D3T, 3H-1,2-dithiole-3-thione Nqo1, NAD(P)H:quinone oxidoreductase 1 GCLC, glutamate cysteine ligase catalytic subunit GCLM, glutamate cysteine ligase modifier subunit BSO, L-buthionine-sulfoxamine DTNB, 5′,5-dithio-bis(2-nitrobenzoic acid) MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide BUN, blood urea nitrogen ARE, antioxidant response element HO-1, heme oxygenase-1 |
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