| 生物响应MRI对比剂的研究进展 |
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| 引用本文： | 曾琦,王天宇,唐建斌. 生物响应MRI对比剂的研究进展[J]. 磁共振成像, 2014, 0(5): 381-386 |
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| 作者姓名： | 曾琦 王天宇 唐建斌 |
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| 作者单位： | 浙江大学生物纳米工程中心化学工程与生物工程学系,杭州,310027 |
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| 基金项目： | 国家自然科学基金(编号21174128)；教育部博士点基金(编号20090101120159)；浙江省钱江人才计划 |
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| 摘 要： | 不同组织和疾病都存在特异性的生物信号。开发能对这些生物信号响应的磁共振成像（MRI）对比剂，不仅有望增加MRI检测疾病的灵敏度，而且能够对病变产生的信号进行分子成像，提高疾病诊断的准确度。该文详细综述了白蛋白、pH、金属离子、酶、氧化还原以及其他生物分子等响应对比剂的最新进展，对未来的研究方向做了展望。
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| 关 键 词： | 磁共振成像 造影剂 |
Research progress in bio-responsive MRI contrast agent |
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| ZENG Qi,WANG Tian-yu,TANG Jian-bin. Research progress in bio-responsive MRI contrast agent[J]. Chinese Journal of Magnetic Resonance Imaging, 2014, 0(5): 381-386 |
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| Authors: | ZENG Qi WANG Tian-yu TANG Jian-bin |
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| Affiliation: | (Department of Chemical and Biological Engineering, Center for Bioengineering, Zhejiang University, Hangzhou 310027, China) |
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| Abstract: | Different tissues and diseases have specific biological signals. The development of magnetic resonance imaging （MRI） contrast agents responding to these signals can not only improve the sensitivity of disease detection by MRI, but also increase the accuracy of disease diagnosis through molecular imaging of these disease signals. This paper gives a review of MRI contrast agents responding to albumin, pH, metal ion, enzyme, redox and other biological signals with the focus on the latest developments and perspectives. |
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| Keywords: | Magnetic resonance imaging Contrast media |
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