酒依赖患者的反应抑制和工作记忆研究

目的 了解酒依赖患者是否存在反应抑制和工作记忆损害.方法 选取48例酒依赖患者为病例组,另外选取50例在年龄、性别、平均智商、平均受教育年限与病例组相匹配的正常人为对照组.运用神经心理学测试的方法比较两组之间反应抑制、工作记忆任务的差异.结果 病例组在执行抑制任务时误按数显著高于对照组（7.02±3.48）次vs （3.45±1.52）次],反应时显著长于对照组（605.45±142.56）ms vs （435.72±51.18）ms],差异有统计学意义（t=6.534,P=0.000;t=7.781,P=0.000）.酒依赖患者在完成空间工作记忆任务时误按数显著提高（4.58±3.45）次vs （0.43±0.88）次],反应时（10 566.16±2 455.61） ms vs（9 185.44±2 677.52） ms]明显增加（t=8.085,P=0.000;t=2.657,P=0.009）.结论 酒依赖患者存在抑制功能及工作记忆缺陷.

Study on response inhibition and working memory in alcohol dependent patients

Objective To detect the impairment of response inhibition and working memory in patients with alcohol dependence.Methods A total of forty-eight alcohol dependent patients and fifty age,gender,IQ,education matched controls were recruited.Neuropsychological tests were applied to measure the differences of response inhibition and working memory between the two groups.Results In the response inhibition task,the patient group had more commission errors （（7.02± 3.48） vs （3.45± 1.52）） and longer reaction time （（605.45 ± 142.56）ms vs （435.72±51.18）ms） compared to the control group （t=6.534,P=0.000; t=7.781,P=0.000）.In the spacial working memory task,the patient group also had more commission errors （（4.58± 3.45） vs （0.43± 0.88）） and longer reaction time（（10566.16±2455.61） ms vs （9185.44±2677.52） ms） than control （t=8.085,P =0.000; t=2.657,P=0.009）.Conclusion There are significant deficiencies in response inhibition and working memory in patients with alcohol dependence.