原发性高血压患者颈动脉粥样硬化与幽门螺杆菌感染的相关性研究

目的探讨原发性高血压(EH)患者颈动脉粥样硬化(CAS)与幽门螺杆菌(Hp)感染的相关性。方法选择2012—2013年我院收治的EH患者150例为EH组,同期在我院体检健康者50例为对照组。检测两组受试者的颈动脉内膜中层厚度(CAIMT)、幽门螺杆菌抗体(Hp-IgG)、血脂及血清高敏C反应蛋白(hs-CRP)、同型半胱氨酸(HCY)水平。结果根据CAIMT和Hp-IgG检查结果将EH组患者分为CAIMT增厚组89例和CAIMT非增厚组61例,Hp感染组67例和Hp非感染组83例。EH组CAIMT1.0 mm者所占比例(59.3%)和Hp-IgG阳性者所占比例(44.7%)均高于对照组(12.0%,28.0%)(P0.05)。CAIMT增厚组Hp-IgG阳性者所占比例(55.1%)高于CAIMT非增厚组(29.5%)(P0.05),Hp感染组CAIMT1.0 mm者所占比例(73.1%)高于Hp非感染组(48.2%)(P0.05)。直线相关分析结果显示,CAIMT增厚与Hp感染率呈正相关(r=0.787,P0.01)。Hp感染组血清TG、TC、LDL-C、HCY、hs-CRP高于Hp非感染组,HDL-C水平低于Hp非感染组(P0.01)。结论 EH患者CAS的发生与Hp感染有关,Hp感染可能通过影响机体炎性反应、血脂代谢及HCY水平促进CAS的发生和发展,清除或预防Hp感染可能是防治EH患者发生CAS的策略之一。

Correlation between Carotid Artery Atherosclerosis and Helicobacter Pylori Infection in Patients with Essential Hyperten-sion

Objective To investigate the correlation between carotid artery atherosclerosis（CAS） and helicobacter pylori（Hp）infection in patients with essential hypertension（EH）. Methods From 2012 to 2013,a total of 150 EH patients were chosen as research group,50 healthy cases were chosen as control group. The CAIMT,Hp - IgG,blood lipid and serum levels of hs - CRP,HCY were detected. Results 89 patients′CAIMT were larger than 1. 0 mm in research group while the other 61 patients were not,and 67 patients got Hp infection while the other 83 patients did not. The rates of CAIMT 〉 1. 0 mm （59. 3% ）,Hp - IgG positive（44. 7% ）in research group were higher than those in control group（12. 0% ,28. 0% ）（P 〈0. 05）. The rate of Hp - IgG positive（55. 1% ）in patients whose CAIMT were larger than 1. 0 mm was higher than that in pa-tients whose CAIMT were not（29. 5% ）（P 〈 0. 05）;the rate of CAIMT 〉 1. 0 mm（73. 1% ）in patients who got Hp infection was higher than that in patients who did not（48. 2% ）（P 〈 0. 05）. By linear correlation analysis,CAIMT was positively corre-lated with the rate of Hp infection in EH patients（ r = 0. 787,P 〈 0. 01）. Serum levels of TG,TC,LDL - C,HCY and hs - CRP were significantly higher in patients who got Hp infection than those in patients who did not（P 〈 0. 01）,serum HDL -C level was significantly lower（P 〈 0. 01）. Conclusion Onset of CAS is correlated with Hp infection in EH patients,it may affect the blood lipid metabolism,inflammatory reaction and HCY levels to promote the development of CAS,removement or pre-vention of Hp infection may be one of the strategies for preventing and treating CAS in EH patients.