The influence of cold on pain during intravenous induction of anaesthesia with propofol in children

Pain on injection and quality of induction were compared in 74 children (5–12 years) randomly assigned to receive either 5 mg·kg^?1 of cold propofol (group A), 5 mg·kg^?1 of cold propofol mixed with lignocaine 1% (group B) or 5 mg·kg^?1 of propofol at room temperature (22–23°C) mixed with lignocaine 1% (group C). The group receiving cold propofol had to be stopped due to a very high incidence of pain (70%). The incidence of pain on injection was 3% in group B and 17% in group C (not significant). Quality of induction and side-effects were similar in the two groups.