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Successful treatment of pediatric plasmacytoid dendritic cell tumors with a contemporary regimen for acute lymphoblastic leukemia |
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| Authors: | Karen D. Wright MD MS Mihaela M. Onciu MD Elaine Coustan‐Smith MS Dario Campana MD PhD Susana C. Raimondi PhD Hiroto Inaba MD PhD Raul Ribeiro MD Ching‐Hon Pui MD John T. Sandlund MD |
| Affiliation: | 1. Department of Oncology, St. Jude Children's Research Hospital, University of Tennessee College of Medicine, Memphis, Tennessee;2. Department of Pathology, St. Jude Children's Research Hospital, University of Tennessee College of Medicine, Memphis, Tennessee;3. Cytogenetics Laboratory, St. Jude Children's Research Hospital, University of Tennessee College of Medicine, Memphis, Tennessee |
| Abstract: | Dendritic cell leukemia (DCL) or hematodermic tumor is an uncommon subtype of acute leukemia. In contrast to adult cases, children tend to have a less aggressive course. The diagnosis of DCL should be considered when its characteristic morphologic features are present and leukemic cells co‐express CD4 and CD56. Cases of DCL among pediatric patients have been reported to respond to therapeutic regimens for acute lymphoblastic leukemia, but details regarding the specifics of therapy are lacking. Pediatr Blood Cancer 2013; 60: E38–E41. © 2013 Wiley Periodicals, Inc. |
| Keywords: | CD4 CD56 dendritic cell hematodermic tumors leukemia |