高血压合并阻塞性睡眠呼吸暂停低通气综合症联合治疗的疗效观察

目的：抗高血压药物、经鼻持续气道正压通气（nCPAP）联合治疗高血压合并阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者，评价联合治疗是否优于药物治疗。方法：72例合并OSAHS的高血压患者随机分为治疗组和对照组各36例：治疗组在常规抗高血压药物治疗的同时进行nCPAP治疗，对照组仅予常规抗高血压药物治疗。6个月后分析两组治疗前后血压及睡眠呼吸监测参数变化。结果：治疗组收缩压（SBP）、舒张压（DBP）、脉压（PP）、心率（HR）、睡眠呼吸暂停低通气指数（AHI）、最长呼吸暂停时间和最低脉搏容积血氧饱和度与对照组比较差异有统计学意义（P〈0．01）。结论：nCPAP联合抗高血压药物是治疗高血压并OSAHS患者的一种有效方法。

Clinical Observation of Combined Treatment in Patients with Hypertension Complicated with Obstructive Sleep Apnea Hypopnea Syndrome

Objective:To evaluate the efficiency of anti- hypertensive medicine amhined with nasal continuous positive airway pressure (nCPAP) on patients of hypertension complicated with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: Seventy-two cases of hypertension complicated with OSAHS were randomly divided into treatment group and control group(n=36). NCPAP and routine drug treatment were administed in the treatment group, while routine drug treatment was given in the control group. Blood pressure and parameters of sleep respiration in two groups were analyzed after six months. Results: SBP, DBP, PP, heart rate, apnea hypopnea index (AHI), maximum apnea duration and minimum pulse oxygen saturation were significantly improved in treatment group, compared to control group (P<0.01). Conclusion: The antihypertensive medicine combined with nCPAP was an effective therapy in hypertension complicated with OSAHS.