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| 多巴胺D2受体-141C Ins/Del多态与海洛因渴求的关系 | |
| 引用本文： | 邵春红,江开达,李一峰,赵敏,林灵,徐一峰,王秋颖. 多巴胺D2受体-141C Ins/Del多态与海洛因渴求的关系[J]. 中国临床心理学杂志, 2005, 13(3): 309-311 |
| 作者姓名： | 邵春红 江开达 李一峰 赵敏 林灵 徐一峰 王秋颖 |
| 作者单位： | 1. 复旦大学附属华山医院精神科,上海,200040;上海市精神卫生中心,上海,200030 2. 上海市精神卫生中心,上海,200030 3. 复旦大学生命学院遗传所 |
| 基金项目： | 上海市卫生局科技发展基金(项目号:01417) |
| 摘 要： | 目的：探讨多巴胺D2受体-141C Ins／Del基因多态与线索诱发海洛因渴求程度的关系。方法：对戒断期380名海洛因依赖者实施线索诱发渴求实验，采用PCR-RFLP技术检测其DRD2-141C Ins／Del基因多态，比较不同基因型与线索诱发海洛因渴求程度的关系。结果：DRD2-141C Ins／Del三种多态基因型中，线索暴露前后海洛因渴求程度的差异均无显著性（P〉0．05）。结论：DRD2-141C Ins／Del基因多态可能与线索诱发海洛因渴求的易感性无关。 |
| 关 键 词： | 海洛因依赖 线索 渴求 多巴胺D2受体 多态性 |
| 文章编号： | 1005-3611(2005)03-0309-03 |
| 修稿时间： | 2004-12-31 |
Relationship between DRD2 -141C Ins/Del Polymorphism and Heroin Craving |
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| SHAO Chun- hong,JIANG Kai- da,LI Yi- feng,et al. Relationship between DRD2 -141C Ins/Del Polymorphism and Heroin Craving[J]. Chinese Journal of Clinical Psychology, 2005, 13(3): 309-311 | |
| Authors: | SHAO Chun- hong JIANG Kai- da LI Yi- feng et al |
| Affiliation: | SHAO Chun- hong,JIANG Kai- da,LI Yi- feng,et al Department of Psychiatry,Hua Shan Hospital,Fudan University,Shanghai 200040,China |
| Abstract: | Objective:To explore the relationship between DRD2 - 141C Ins/Del polymorphism and heroin craving. Methods:380 heroin addicts who were under abstinence were given the cue- elicited heroin craving experiment. And then we detected the polymorphism of DRD2- 141CIns/Del for them by using PCR- RFLP. We compared the relationship between genotypes of DRD2- 141CIns/Del and heroin craving before and after cue exposure. Results:No significant differ- ence has been found between heroin craving before and after cue- exposure in three genotypes of DRD2- 141CIns/Del. Conclusion:D2 receptor gene - 141CIns/Del polymorphisms may have no association with the susceptibility of heroin crav- ing. |
| Keywords: | Heroin Dependence Cue Craving Dopamine D2 receptor Polymorphism |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |