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| RECK蛋白表达与舌鳞癌淋巴结转移和浸润的相关研究 | |
| 引用本文： | 姚金光,李龙江,邝晓聪,温冠媚. RECK蛋白表达与舌鳞癌淋巴结转移和浸润的相关研究[J]. 广西医科大学学报, 2006, 23(4): 536-537 |
| 作者姓名： | 姚金光 李龙江 邝晓聪 温冠媚 |
| 作者单位： | 广西右江民族医学院口腔学教研室,百色,533000;四川大学华西口腔医学院口腔颌面外科,成都,610041;广西医科大学病理生理学教研室,南宁,530021 |
| 基金项目： | 广西科学研究与科技开发计划项目 |
| 摘 要： | 目的:探讨RECK蛋白表达水平与舌癌侵润和淋巴转移的关系.方法:选取舌癌标本59例,采用免疫组化与图像分析系统,检测RECK、MMP-9蛋白表达情况,并与舌癌的临床特征进行相关分析.结果:RECK蛋白的低表达水平与舌癌的浸润和淋巴结转移有关,而且与MMP-9蛋白表达水平呈负相关,相关系数为-0.415.结论:RECK蛋白高水平表达可降低舌癌的侵袭与转移,其调控机制可能与RECK蛋白可能抑制MMP-9蛋白表达有关. |
| 关 键 词： | 舌鳞状细胞癌 RECK蛋白 基质金属蛋白酶 淋巴道转移 |
| 收稿时间： | 2006-04-28 |
| 修稿时间： | 2006-04-28 |
RECK EXPRESSION CORRELATION WITH LYMPHATIC METASTASIS AND INVASION IN PATIENTS WITH TONGUE SQUAMOUS CELL CANCER |
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| Yao Jingguang,Li Longjiang, Kuang Xiaocong,et al.. RECK EXPRESSION CORRELATION WITH LYMPHATIC METASTASIS AND INVASION IN PATIENTS WITH TONGUE SQUAMOUS CELL CANCER[J]. Journal of Guangxi Medical University, 2006, 23(4): 536-537 | |
| Authors: | Yao Jingguang Li Longjiang Kuang Xiaocong et al. |
| Affiliation: | Department of Stomatology, YouJiang Medical College for Nationatities,Baise 533000 China |
| Abstract: | Objective:To explore the relationship between expression level of RECK and invasion and lymphatic metastasis of tongue squamous cell carcinoma.Methods:Immunohistochemical staining of RECK,MMP-2,MMP-9 were performed by using specimens from 59 patients with tongue squamous carcinoma.The correlations among the RECK with MMP-2,MMP-9 and RECK with clinico-pathological features were analyzed by chi-square test and spearman correlation.Result:Among the 59 tongue squamous carcinoma samples,the patients who had tumors with high RECK expression showed significantly less invasion and lymph nodes metastasis than those with low RECK expression,and the level of RECK expression had significant inverse correlation with MMP-9 expression.Conclusion:Our research shows that RECK can suppress invasion and metastasis of tongue squamous carcinoma. |
| Keywords: | tongue squamous cell carcinoma RECK gene matrix metalloproteinase lymphatic metastasis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |