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Effect of the timing of gluten introduction on the development of celiac disease
Authors:Marco Silano  Carlo Agostoni  Stefano Guandalini
Affiliation:Marco Silano, Unit of Human Nutrition and Health, Italian National Institute of Health, Rome 00161, ItalyCarlo Agostoni, Department of Maternal and Pediatric Sciences, University of Milan, Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico, Milano 20122, ItalyStefano Guandalini, Department of Pediatrics Section of Gastroenterology, Hepatology and Nutrition, University of Chicago, Chicago, IL 60637, United States
Abstract:
Celiac disease(CD) is a permanent auto-immune enteropathy,triggered in genetically predisposed individuals by the ingestion of dietary gluten.Gluten is the alcohol-soluble protein component of the cereals wheat,rye and barley.CD is a multifactorial condition,originating from the interplay of genetic and environmental factors.The necessary environmental trigger is gluten,while the genetic predisposition has been identified in the major histocompatibility complex region on chromosome 6p21,with over 90% of CD ...
Keywords:Celiac disease  Gluten  Weaning  Breastfeeding  Prevention  Autoimmunity  Anti-transglutaminase antibody  Duodenal biopsy
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点击此处可从《World journal of gastroenterology : WJG》浏览原始摘要信息
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