血小板减少性紫癜患儿治疗前后血清IL-2、SIL-2R检测的临床意义

目的:分析了31例血小板减少性紫癜患儿治疗前后血清IL-2、SIL-2R水平的变化。方法:采用放射免疫分析检测患者血中IL-2含量和ELISA法检测SIL-2R含量,并与35名正常健康儿童作比较。结果:治疗前血清IL-2水平明显低于正常人,SIL-2R水平明显高于正常人(P<0.01),经1个月治疗后,血清IL-2和SIL-2R与正常人比较无显著差异(P>0.05)。结论:观察血小板减少性紫癜患者的免疫功能变化与患者的病情和预后密切相关。

Clinical Significance of Measurement of Changes of Serum IL-2, SIL-2R Levels After Treatment in Patients with Thrombocytopenic Purpura

Objective To study the changes of serum IL-2 and SIL-2R levels after treatment in 31 patients with thrombocytopanic purpura. Methods Serum IL-2 (with RIA) and SIL-2R (with ELISA) levels were measured in 31 patients with thrombocytopanic purpura both before and after treatment as well as in 35 controls. Results Before treatment, in the patients the serum IL-2 levels were significantly lower and serum SIL-2R levels were significantly higher than those in the controls (P<0.01), after treatment for one month, the serum IL-2, SIL-2R levels were not significantly different from those in controls (P>0.05). Conclusion Cytokines IL-2 and SIL-2R levels changes could reflect the immunostatus of the patients as well as the progress of diseases and could be of prognostic values.