氯吡格雷联合阿司匹林治疗急性心肌梗死的疗效观察

目的:观察氯吡格雷联合阿司匹林治疗急性心肌梗死(acute myocardial infarction,AMI)的疗效。方法:将2012年2月—2013年5月收治的90例AMI患者分为观察组(n=45)和对照组(n=45)。观察组在常规治疗基础上加用氯吡格雷联合阿司匹林治疗,对照组在常规治疗基础上加用氯吡格雷治疗。比较两组患者的临床疗效、冠状动脉再通率、再通时间、左心室射血分数(LVEF)、再闭塞率、血小板聚集率(PAR)、凝血酶原时间(PT)、凝血酶原活动度(PA)、活化部分凝血酶原时间(APTT)以及心血管事件发生率和患者出血率。结果:观察组患者的临床疗效、冠状动脉再闭塞发生率、心血管事件发生率以及治疗后的LVEF和PAR均显著优于对照组(P0.05),但是两组患者的冠状动脉再通率、再通时间、出血发生率以及治疗前后的PT、PA和APTT差异无统计学意义(P0.05)。结论:氯吡格雷联合阿司匹林治疗急性心肌梗死疗效良好,值得临床推广。

Efficacy of Clopidogrel Combined with Aspirin in Acute Myocardial Infarction

Objective： To observe the efficacy of clopidogrel combined with aspirinin acute myocardial（AMI） Methods：A total of 90 AMI patients from February 2012 to May 2013 were divided into observation group （n = 45） and control group （n = 45）. Patients in the observation group received clopidogrel combined with aspirin in addition to regular therapy for AMI, while patients in the control group only received aspirin besides regular therapy for AMI, Clinical efficacy, coronary artery recanalization rate, recanalization time, left ventricular eiection fraction （LVEF）, coronary artery reocelusion rate, platelet aggregation rate （PAR）, prothrombin time （PT）, prothrombin activity （PA）, activated partial thromboplastin time （APTT） and rate of cardiovascular events were compared between these two groups. Results： The clinical efficacy, coronary artery reocclusion rate, rate of cardiovascular events, LVEF and PAR in the treatment group were significantly improved than those in the control group （P〈0.05）. However, there were no significant differences in the coronary artery recanalization rate, recanalization time, PT, PA and APTT between these two groups （P〉0.05）. Conclusions： Treatment of clopidogrel combined with aspirin in AMI can improve the clinical efficacy.