Characterization of Th1- and Th2-type immune response in human multidrug-resistant tuberculosis |
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| Authors: | Q. Tan W. P. Xie R. Min G. Q. Dai C.-C. Xu H. Q. Pan C. D. Miao Z. Yang W. G. Xu H. Wang |
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| Affiliation: | (1) Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China;(2) The Third Hospital of Zhenjiang City, Zhenjiang, China;(3) Center for Disease Control and Prevention (CDC) of Taizhou City, Taizhou, China;(4) Jiangbei Hospital, Nanjing, China;(5) Center for Disease Control and Prevention of Jiangsu Province, Nanjing, China |
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| Abstract: | ![]()
Multidrug-resistant tuberculosis (MDR-TB) has become a lethal global threat. Insights into the immune regulation of MDR-TB are urgently needed for the development of new treatments; however, the T cell response to an MDR-TB infection in human remains unclear. In the present study, the proportion of Th1 and Th2 cell subsets and the level of related T cell subset cytokines in peripheral blood were investigated. We detected that an MDR-TB infection resulted in suppressed Th1 and Th2 cell activation, which was more remarkable in patients with MDR-TB than that in drug-sensitive tuberculosis (DS-TB) sufferers when compared to healthy controls (HCs). In addition, MDR-TB infection down-regulated the expression of IFN-γ, IL-2, and IL-10, and up-regulated IL-4, IL-6, and TNF-α expression. Our data suggest that the disturbance between protective and pathogenic effects induced by the immunosuppression of Th1- and Th2-type responses is a substantial characteristic of MDR-TB infections. |
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