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Antimetastatic activity and low systemic toxicity of tetradecyl gallate in a preclinical melanoma mouse model
Authors:Claudriana Locatelli  Deborah Regina Carvalho  Alessandra Mascarello  Clarissa Amorin Silva de Cordova  Rosendo Augusto Yunes  Ricardo Jose Nunes  Celso Pilati  Tania Beatriz Creczynski-Pasa
Affiliation:(1) Departamento de Ci?ncias Farmac?uticas, Centro de Ci?ncias da Sa?de, Universidade Federal de Santa Catarina, 88040-900 Florian?polis, SC, Brazil;(2) Curso de Farm?cia, Universidade Alto Vale do Rio do Peixe, 89500-000 Ca?ador, SC, Brazil;(3) Departamento de Qu?mica, Centro de Ci?ncias F?sicas e Matem?ticas, Universidade Federal de Santa Catarina, 88040-900 Florian?polis, SC, Brazil;(4) Escola de Medicina Veterin?ria e Zootecnia, Campus Universit?rio de Aragua?na, Universidade Federal do Tocantins, 77804-970 Aragua?na, TO, Brazil;(5) Departamento de Medicina Veterin?ria, Centro Agroveterin?rio, Universidade do Estado de Santa Catarina, 88520-000 Lages, SC, Brazil;
Abstract:Gallates with eight or more carbon atoms in the lateral chain show potent anticancer activity against various cell lines. However, studies regarding the in vivo antimelanoma activity of tetradecyl gallate (C14) have not yet been reported. In this study an evaluation of the ability of C14 to inhibit metastasis, using lung metastases as a model, was carried out. The experimental mouse melanoma model was established by intravenous injection of metastatic B16F10 melanoma cells. The systemic toxicity of C14 was evaluated in vivo by monitoring the weight, survival, biochemical and hematological parameters, and through histological analysis. It was observed that C14 decreased lung metastasis in vivo by 80% and increased the survival rate of the animals without toxic effects. Additionally, C14 induced cytotoxic effects on B16F10 cells, inhibited the inter-cellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) expression, and significantly decreased cell adhesion. These results reveal that C14 has potent antimetastatic ability and is a good candidate for further study as a potential therapeutic agent for tumor metastases.
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