| 缩氨基硫脲衍生物JOH-1对K562细胞增殖的影响 |
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| 引用本文： | 刘路,范红义,张昀,姬汴生. 缩氨基硫脲衍生物JOH-1对K562细胞增殖的影响[J]. 河南大学学报(医学版), 2014, 0(2): 123-125 |
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| 作者姓名： | 刘路 范红义 张昀 姬汴生 |
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| 作者单位： | 刘路 (河南大学药学院,河南开封,475004)； 范红义 (河南大学药学院,河南开封,475004)； 张昀 (河南大学药学院,河南开封,475004)； 姬汴生 (河南大学天然药物与免疫重点实验室,河南开封,475004)； |
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| 摘 要： | 目的探讨JOH-1对体外培养人白血病K562细胞株增殖的影响。方法以JOH-1为研究对象,采用细胞体外培养技术,MTT法和台盼蓝拒染法检测JOH-1对K562细胞株增殖抑制。结果不同浓度的JOH-1作用于K562细胞12、24、48h后对K562细胞的增殖有抑制作用,且呈剂量和时间依赖性;生长曲线显示JOH-1使K562细胞的生长受到明显抑制。结论 JOH-1对体外培养人白血病K562细胞株的增殖有显著抑制作用,且呈剂量和时间依赖性。
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| 关 键 词： | JOH-1 K562细胞 增殖抑制 影响 |
Effect of JOH-1, a thiosemicarbazide derivative,on the proliferation of K562 cells |
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| LIU Lu,FAN Hongyi,ZHANG Yun,JI Biansheng. Effect of JOH-1, a thiosemicarbazide derivative,on the proliferation of K562 cells[J]. Journal of Henan University, 2014, 0(2): 123-125 |
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| Authors: | LIU Lu FAN Hongyi ZHANG Yun JI Biansheng |
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| Affiliation: | 1. Pharmacy College, Henan University, Kaifeng, Henan 475004, China; 2. The Key Laboratory of Natural Drug and Immune Engineering, Henan University, Kaifeng, Henan 475004, China) |
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| Abstract: | Objective To investigate the impact of JOH1 on the proliferation of K562 cells .Methods The suppression of K562 cells growth was detected by MTT assay and trypan blue exclusion .Results JOH1 inhibited the proliferation of K562 cells in dose and time dependent manner . The growth curve showed that the growth of K562 cells was inhibited .Conclusion JOH1 can obviously inhibit the proliferation of K562 cells ,in a time and dose dependent manner . |
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| Keywords: | K562 cells Proliferation inhibition infection |
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