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Role of aetiology in the progression,regression, and parenchymal remodelling of liver disease: implications for liver biopsy interpretation |
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| Authors: | Alberto Quaglia Venancio A Alves Charles Balabaud Prithi S Bhathal Paulette Bioulac‐Sage James M Crawford Amar P Dhillon Linda Ferrell Maria Guido Prodromos Hytiroglou Yasuni Nakanuma Valerie Paradis Dale C Snover Neil D Theise Swan N Thung Wilson M S Tsui Dirk J van Leeuwen The International Liver Pathology Study Group |
| Affiliation: | 1. Institute of Liver Studies, King's College Hospital and King's College, London, UK;2. Department of Pathology, University of S?o Paulo School of Medicine, S?o Paulo, Brazil;3. Inserm, U1053, Bordeaux University 2, Bordeaux, France;4. Department of Pathology, University of Melbourne, Melbourne, VIC, Australia;5. Department of Pathology, CHU Bordeaux, Bordeaux, France;6. Department of Pathology and Laboratory Medicine, Hofstra Northwell School of Medicine, Hempstead, NY, USA;7. Department of Cellular Pathology, UCL Medical School, London, UK;8. Department of Pathology, University of California, San Francisco, CA, USA;9. Department of Medicine‐DIMED, Pathology Unit, University of Padova, Padova, Italy;10. Department of Pathology, Aristotle University Medical School, Thessaloniki, Greece;11. Department of Diagnostic Pathology, Shizuoka Cancer Center, Shizuoka, Japan;12. Pathology Department, Beaujon Hospital, Clichy, France;13. Department of Pathology, Fairview Southdale Hospital, Edina, MN, USA;14. Departments of Pathology and Medicine (Division of Digestive Diseases), Beth Israel Medical Center of Albert Einstein College of Medicine, New York, NY, USA;15. Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA;16. Department of Pathology, Caritas Medical Centre, Hong Kong, China;17. Section 18. of Gastroenterology and Hepatology, Dartmouth Medical School, Hanover, NH, USA;19. Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands |
| Abstract: | Clinicopathological concepts on acute and chronic liver disease have evolved rapidly during the last few years, with advances in general and specific treatment options and improved patient outcomes. The old paradigm of ‘irreversibility’ of cirrhosis had been challenged in major ways, and the validity of the usage of the term ‘cirrhosis’ has come into question. This paper addresses aetiology‐based clinicopathological concepts and features that may deserve attention because they may determine disease outcome and, specifically, patterns of regression and remodelling. A variety of therapeutic interventions may influence remaining disease features after elimination of damaging agents (virus, alcohol, etc.), and determine the final clinical outcome including the risk of hepatocellular carcinoma (HCC). New concepts create new responsibilities and opportunities for the pathologist to contribute to the understanding of liver pathology and communicate this with clinical colleagues and researchers. |
| Keywords: | biopsy end stage liver disease fibrosis liver cirrhosis liver regeneration |