Home Use of Mini-Dose Glucagon As a Novel Treatment for Hypoglycemia Following Repeated,Prolonged Fasts in Type 1 Diabetes During Ramadan |
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| Authors: | Metab Algeffari Sufyan Hussain Turki Almogbel Mansour Alsharidah Habibah Alghadouni Farid Mahmood |
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| Affiliation: | 1.Department of Family and Community Medicine, College of Medicine, Qassim University, Buraydah, Saudi Arabia;2.Diabetes & Endocrinology, Guy''s and St Thomas'', London, U.K.;3.Department of Diabetes, King''s College London, London, U.K.;4.Diabetes and Endocrinology Center, King Fahd Specialist Hospital, Buraydah, Saudi Arabia;5.Department of Physiology, College of Medicine, Qassim University, Buraydah, Saudi Arabia |
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| Abstract: | OBJECTIVEWe determined the efficacy of self-administered subcutaneous mini-dose glucagon (MDG) to treat fasting-induced hypoglycemia in type 1 diabetes (T1D).RESEARCH DESIGN AND METHODSThis was a 4-week randomized, controlled crossover trial of 2-week MDG or 2-week oral glucose tablets (OG, control) involving 17 adults with T1D during Ramadan.RESULTSCompared with OG, MDG demonstrated a significant higher change in blood glucose from baseline to 30 min (Δt30, P < 0.001) and 1 h (Δt60, P = 0.02). The efficacy of MDG was preserved following ≥8 h fasting with significantly higher Δt30 in MDG (P = 0.01). Over the entire 2 weeks, MDG period had increased time in 70–180 mg/dL (P = 0.009) and less time <70 mg/dL (P = 0.04). MDG use resulted in higher completion of fasts compared with OG (P < 0.001).CONCLUSIONSMDG administration is an effective alternative to OG for prevention and treatment of fasting-induced hypoglycemia, offering improved glycemic control and promoting successful completion of prolonged fasts. |
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