绿原酸对肝纤维化大鼠脂质过氧化作用的影响

目的 研究绿原酸（CGA）对肝纤维化大鼠脂质过氧化作用的影响.方法 采用皮下注射CCl4诱导大鼠肝纤维化,以绿原酸（100 mg/kg）同时灌服给药8周,检测对照组、模型组和绿原酸组大鼠血清、肝组织中丙二醛（MDA）含量和超氧化物歧化酶（SOD）活性,病理检测肝纤维化进展.结果 绿原酸能显著降低肝纤维化大鼠血清、肝组织中MDA含量,提高SOD的活性,抑制肝纤维化形成.结论 绿原酸具有很明显的保护肝细胞、抗肝纤维化的作用,其机制可能与抗脂质过氧化有关.

Effect of Chlorogenic Acid on Lipid Peroxidation in Rat with Hepatic Fibrosis

Objective To study the effect of chlorogenic acid（CGA） on lipid peroxidation in rat with hepatic fibrosis. Methods Subcuta- neous injection of CCI4 was adopted to induce rat with hepatic fibrosis. At the same time, rats were gavaged with CGA（100 mg/kg） for 8 weeks. The levels of malondialdehyde（MDA） and supemxide dismutase（SOD） activities in serum and liver tissue were determined in the control, model and CGA groups and the hepatic fibrosis progress was pathologically determined. Results CGA could obviously decrease the MDA level in serum and liver tissue, increase the SOD activity and inhibit the formation of hepatic fibrosis. Conclusion CGA has the obvious effects on protecting hepatocytes and anti- hepatic fibrosis, its mechanism may be related with its anti- lipid peroxidation.