氟喹诺酮类药物的不良反应及合理用药分析

目的分析和研究氟喹诺酮类药物的不良反应及应用规律,指导临床合理用药。方法归纳总结124例氟喹诺酮类药物不良反应情况。结果氟喹诺酮类药物用药后,不良反应多发生于胃肠道以及中枢神经系统,涉及不良反应较多的四类药物分别为左氧氟沙星（46.8%）、环丙沙星（28.2%）、加替沙星（18.5%）,其中不良反应发生的主要给药途径为静脉注射。结论为了有效减少和防止氟喹诺酮类药物不良反应发生,临床用药中要根据规范要求用药,可有效减少不良反应,提高临床效果。

Analysis of the adverse reaction of fluoroquinolones and rational drug use

Objective This paper aims to analyze and study adverse reactions and application laws of fluoroquinolones drugs, and to guide rational drug use clinically.Methods 124 adverse reactions of fluoroquinolone drugs are summarized.Results After taking fluoroquinolone drugs, adverse reactions mainly occur in the gastrointestinal tract and the central nervous system, there are four drugs involving major adverse reactions, including levofloxacin（46.8%）, ciprofloxacin（28.2%）, and gatifloxacin（18.5%）, in which the main route of medication causing adverse reactions is intravenous injection.Conclusion In order to effectively reduce and prevent the adverse reactions of fluoroquinolone drugs, clinical drugs should be used according to the regulations, so as to effectively reduce the adverse reaction and improve the clinical effect.