Ultrastructural Effects of Acute Organophosphate Poisoning on Rat Kidney |
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| Authors: | Salim Satar Deniz Satar Ufuk Ozgu Mete Jeffrey R Suchard Metin Topal Mehmet Kaya |
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| Institution: | 1. Department of Emergency Medicine, School of Medicine, ?ukurova University, Balcali/Adana, Turkeyssatar@cu.edu.tr;3. Pathology Department, Adana Numune Education and Research Hospital, Balcali/Adana, Turkey;4. Department of Histology and Embryology, School of Medicine, ?ukurova University, Balcali/Adana, Turkey;5. Department of Emergency Medicine, University of California Irvine Medical Center, Orange, CaliforniaUSA;6. Department of Emergency Medicine, School of Medicine, ?ukurova University, Balcali/Adana, Turkey |
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| Abstract: | We investigated the ultrastructural effects of the organophosphate compound methamidophos and treatment with atropine and pralidoxime (2-PAM) on rat kidneys. Male Wistar albino rats were assigned to four groups. Group 1 received 30 mg/kg methamidophos, the LD50 for this compound in rats, via oral gavage. Group 2 received only physiologic saline. Group 3 rats received 30 mg/kg methamidophos and were treated with 2-PAM and atropine via intraperitoneal injection when cholinergic symptoms were noted. Group 4 served as a control, and received physiologic saline in equivalent volumes and routes to Group 3. Kidney tissues were prepared for electron microscopic studies. No ultrastructural changes were detected in Group 1 after acute poisoning with methamidophos and in Group 3 treated with antidotes after poisoning. Acute organophosphate poisoning and antidotal treatment in this model are not associated with histopathological changes in the rat kidney but the models with different organophosphate compounds, by administrating the different dosages, may be more illuminative in explaining the effects of these chemicals in kidney. |
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| Keywords: | atropine kidney organophosphate poisoning pralidoxime treatment ultrastructure |
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