Low Plasma Dehydroepiandrosterone Sulfate Level and its Relationship to Adiponectin in Hemodialysis Patients

The aim of the present study was to assess the relationship between plasma DHEA-S and adiponectin concentrations in hemodialyses patients (HD). Plasma adiponectin, DHEA-S, cholesterol, and albumin levels were estimated in 94 HD and 46 healthy subjects (HS). In HD, a significantly lower plasma DHEA-S concentration (2.5±0.2 vs. 4.7±0.4 μmol/L respectively; p?=?0.002) but significantly higher plasma adiponectin level (15.0±0.7 vs. 8.7±0.8 μg/mL respectively; p?=?0.004) than in HS were found. Only in uremic patients was a significant negative correlation found between plasma adiponectin and DHEA-S concentrations (tau?=?–0.210; p?=?0.001). Decreased plasma DHEA-S level is associated with increased adiponectinemia in uremic patients.