EXPRESSION OF PTEN AND SHP1, INVESTIGATED FROM TISSUE MICROARRAYS IN PEDIATRIC ACUTE LYMPHOBLASTIC,LEUKEMIA |
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| Authors: | Fredrika Gauffin Eva Diffner Bertil Gustafsson Ann Nordgren Anette Gjörloff Wingren Birgitta Sander |
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| Affiliation: | 1. Department of Clinical Science, Intervention and Technology (CLINTEC), Division of Pediatrics, Karolinska Institutet, Stockholm, Sweden;2. Center for Molecular Pathology, Malm? University Hospital, Malm?, Sweden;3. Department of Pathology, Faculty of Health Sciences, Link?ping University Hospital, Sweden;4. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden;5. Department of Tumor Biology, Lund University, Malm? University Hospital, Malm?, Sweden;6. Department of Laboratory Medicine, Div of Pathology, Karolinska Institutet, Stockholm, Sweden |
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| Abstract: | PTEN and SHP1 are tumor suppressor genes involved in the regulation of cell cycle control and apoptosis. The authors investigated the protein expression of PTEN and SHP1, by immunohistochemistry in tissue microarrays from bone marrow samples in children, diagnosed with acute lymphoblastic leukaemia and nonmalignant controls. PTEN was overexpressed in diagnostic ALL samples, while SHP1 showed a low expression. Both proteins showed a significant difference in expression compared to nonmalignant controls. The roles of PTEN and SHP1 are not well investigated in pediatric leukemia and could in the future play a role as prognostic factors. |
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| Keywords: | pediatric leukemia PTEN SHP1 tissue microarray |
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