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Comparison of Intramuscular and Intradermal Applications of Hepatitis B Vaccine in Hemodialysis Patients
Authors:M. Kasım Karahocagil  Turan Buzgan  Hasan Irmak  Hayrettin Akdeniz  Nevzat Akman
Affiliation:1. Department of Clinical Microbiology and Infectious Diseases, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey;2. Department of Public Health, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey
Abstract:This study compared the application of intramuscular recombinant hepatitis B vaccine in hemodialysis patients with the application of accelerated intradermal recombinant hepatitis B vaccine, which can be applied with one-tenth of the standard dose. Sixty seronegative patients for hepatitis B were randomly separated into two groups. Twenty μg of the recombinant hepatitis B vaccine was intramuscularly applied at 0-, 1-, 2-, and 6-month intervals to the first group (32 cases). One more dose was applied at month 12 to those whose anti-HBs titers remained below 100 mIU/mL at month 7. The same vaccine was intradermally applied at 2μg dose six times with one-month intervals to the second group (28 cases). Vaccine applications were continued in those whose anti-HBs titers remained below 100 mIU/mL at month 7 until antibody titers reached above this value or until the dose number became 12. Measurements of antibody titers were repeated at month 13 in both groups. As a result, in the vaccination of hemodialysis patients against hepatitis B, the accelerated ID application of hepatitis B vaccine with a dose reduced to one-tenth is more cost-effective than the standard dose vaccination schedules. Especially for hemodialysis patients, the time has come for routine application of ID hepatitis B vaccine as an alternative vaccination method.
Keywords:hepatitis B vaccination  intradermal vaccination  hemodialysis
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