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In vitro and in vivo trypanocidal effect of lipophilic extracts of medicinal plants from Mali and Burkina Faso |
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| Authors: | Aderbauer Birgit Clausen Peter-Henning Kershaw Olivia Melzig Matthias F |
| Affiliation: | 1. Department of Pharmacy, Freie Universität Berlin, Königin-Luise-Street, 2+4, D-14195 Berlin, Germany;2. Institute for Parasitology and Tropical Veterinary Medicine, Freie Universität Berlin, Königsweg 67, D-14163 Berlin, Germany;3. Department of Veterinary Pathology, Faculty of Veterinary Medicine, Freie Universität Berlin, Robert-von-Ostertag-Street 15, D-14163 Berlin, Germany |
| Abstract: | AIM OF THE STUDY: To determine the in vitro and in vivo antitrypanosomal activity of extracts of traditionally used plants. MATERIALS AND METHODS: 47 dichloromethane extracts were tested in vitro in the Long-term Viability Assay (LtVA) on Trypanosoma brucei brucei. The most active ones were also tested in vivo using a standardised mouse test. RESULTS: 13 extracts (28%) were active in vitro with MIC-values |
| Keywords: | Securidaca longepedunculata Trypanosoma brucei brucei Medicinal plants Antitrypanosomal activity Acacia nilotica Immunosuppressive activity |
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