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| 人胚肝低密度脂蛋白受体活性与血清胆固醇水平的关系 | |
| 引用本文： | 谢崇伦 蔡海江. 人胚肝低密度脂蛋白受体活性与血清胆固醇水平的关系[J]. 中国病理生理杂志, 1991, 7(3): 225-228 |
| 作者姓名： | 谢崇伦 蔡海江 |
| 作者单位： | 南京医学院病理生理教研室(谢崇伦，蔡海江，陈秀英，陈琪)，南京医学院病理生理教研室(陈毓华) |
| 摘 要： | 用卵磷脂/丙酮沉淀法测定经部分纯化的人胚肝LDL受体活性,结果发现,随着胎龄增加,肝脏LDL受体活性明显增高。与此同时,血清总胆固醇(TC)和LDL-胆固醇(LDL-C)水平进行性下降。胎龄与血清TC和LDL-C的相关系数分别为-0.80和-0.77,有显著意义(P<0.001)。进而发现,在胚肝LDL受体活性与血清TC和LDL-C之间也存在着明显的负相关,相关系数分别为-0.96和-0.95(P<0.001)。这一结果提示,在胎儿发育过程中,肝脏LDL受体对血胆固醇水平调节起着关键的作用。 |
| 关 键 词： | 脂蛋白类 低密度 胆甾醇 胎儿 |
The relation between liver low density lipoprotein (LDL) receptor activity and serum cholesterol levels in human fetus |
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| Xie Chong-Lun,Cai Hai-Jiang,et al. The relation between liver low density lipoprotein (LDL) receptor activity and serum cholesterol levels in human fetus[J]. Chinese Journal of Pathophysiology, 1991, 7(3): 225-228 | |
| Authors: | Xie Chong-Lun Cai Hai-Jiang et al |
| Affiliation: | Xie Chong-Lun,Cai Hai-Jiang,et al Department of Pathophysiology,Nanjing Medical College,Najing |
| Abstract: | The activity of the solubilized receptor was assayed by precipitating the receptor with acetone in the presnce of egg phosphatidyleholine liposomes. It was found that the binding of ~(125)I-LDL to fetal liver receptors rose significantly with the increase of fetal age. During the same period, the total cholesterol (TC) and LDL-eholesterol (LDL-C) levels in fetal serum declined progressively. The correlation between fetal age and concentration of TC and LDL-C were -0.80(P<0.001) and -0.77(P<0.001), respectively. Thus, there was an inverse correlation between the liver LDL recept or activity and the serum TC (r=-0.96, P<0.001) and LDL-C (r=-0.95, P<0.001). It suggested that the LDL receptor in human fetal liver may play a key role in the regulation of the serum cholesterol levels in the fetus during gestation. |
| Keywords: | Lipoproteins LDL Cholesterol Fetus |
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