谷氨酸钠反复注射对家兔体温的影响

本研究用14只新西兰兔进行实验,观察了反复多次使用谷氨酸钠(MSG)对其降温效应的影响。动物分两组,实验组家兔静脉注射中等剂量MSG(0.5g/kg)连续三天,每天一次,体温均明显下降。(与对照组相比,P<0.05)。第四次(时间间隔1周,以同样的剂量和方式注射MSG,则几乎不出现降温作用(与对照组比,P>0.05)。第五次(时间间隔2周)注射MSG的效应与第四次相似。实验结果提示:MSG反复多次使用后,其降温效应逐渐减弱。作者暂称之为“降温耐受”现象,并对降温效应减弱的机制进行初步讨论。

The effect of injection repeatedly of monosodium glutamate on the body temperature in rabbits

Further study of the effect of monosodium glutamate on body temperature using rabbits as experimental model by repeatedly intravenous injection of MSG. The experimental results showed that the body temperature of rabbits were decreased significantly at a time of each day consecutively for three days with medium dose MSG(0.5g/kg/day) However, this effect was disappeared following the fourth administration of MSG a week later, and so did the fifth administration of MSG two weeks later. Those results suggested that the disappearance of decreased body temperature by MSG may be due to tolerance development after MSG was administrated repeatedly. The authors proposed two hypotheses of mechanisms for the development of MSG"tolerance". which would be investigated further.