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| 地塞米松片的溶出度 | |
| 引用本文： | 董军,段更利,刘振,左明,张建芳. 地塞米松片的溶出度[J]. 中国临床药学杂志, 2003, 12(1): 27-29 |
| 作者姓名： | 董军 段更利 刘振 左明 张建芳 |
| 作者单位： | 1. 上海丰华药房,上海,200001 2. 复旦大学药学院药物分析教研室,上海,200032 3. 复旦大学药学院药剂教研室,上海,200032 |
| 摘 要： | 目的：研究并建立地塞米松片溶出度的介质及测定方法。方法：采用转篮法分别以1%盐酸，5%乙醇溶液，10%乙醇溶液，15%乙醇溶液及磷酸盐缓冲液（pH=6.6)5种溶出介质进行地塞米松片的溶出试验。以HPLC法测定溶出介质中地塞米松的浓度。结果：研制片与市售地塞米松片在5%乙醇溶液中45min时的溶出度均大于标示量的79%。结论 所建立的HPLC方法准确。可靠；地塞米松片在5%乙醇溶液中的溶出度符合药典要求。 |
| 关 键 词： | 地塞米松片 溶出度 高效液相色谱法 |
| 文章编号： | 1007-4406(2003)01-0027-03 |
HPLC determination for dissolution of dexamethasone tablets |
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| Dong Jun ,Duan Gengli ,Liu Zheng ,Zuo Ming ,Zhang Jianfang. HPLC determination for dissolution of dexamethasone tablets[J]. Chinese Journal of Clinical Pharmacy, 2003, 12(1): 27-29 | |
| Authors: | Dong Jun Duan Gengli Liu Zheng Zuo Ming Zhang Jianfang |
| Affiliation: | Dong Jun 1,Duan Gengli 2,Liu Zheng 2,Zuo Ming 2,Zhang Jianfang 3 |
| Abstract: | AIM: To establish and evaluate an assay for the dissolution of dexamethason tablets. METHODS: The dissolution tests were performed by a rotating basket method, with 1% hydrochloric acid, 5% alcohol solution, 10% alcohol solution, 15% alcohol solution and phosphate buffer (pH=6.6) as dissolution solvents respectively. The concentration of dexamethasone in dissolution solvents was determined by high performance liquid chromatography (HPLC) method. RESULTS: The dissolution of both kinds of dexamethasone tablets in 5% alcohol solution were both greated than 79% of the labeled amount after 45 min. CONCLUSION: Established method is accurate and reliable for the dissolution test of dexamethasone tablets. |
| Keywords: | dexamethasone tablets dissolution high performance liquid chromatography |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |