The effect of methamphetamine on serotonin and its metabolite in the suprachiasmatic nucleus: A microdialysis study |
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| Authors: | N. Ozaki D. Nakahara Y. Kasahara T. Nagatsu |
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| Affiliation: | (1) Present address: Department of Psychiatry, Nagoya University School of Medicine, Nagoya, Japan;(2) Department of Biochemistry, Nagoya University School of Medicine, Nagoya, Japan;(3) Department of Psychology, Nagoya University College of Medical Technology, Nagoya, Japan |
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| Abstract: | Summary The suprachiasmatic nucleus (SCN) has been identified as a major circadian pacemaker. Methamphetamine has been shown to modify the behavior of circadian rhythms. We detected extracellular serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the SCN in freely moving rats, using a microdialysis method, to investigate biochemical effects of methamphetamine in the SCN. Methamphetamine infusion into the SCN dose-dependently increased extracellular 5-HT and decreased extracellular 5-HIAA. |
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| Keywords: | Suprachiasmatic nucleus microdialysis methamphetamine serotonin 5-hydroxyindoleacetic acid circadian pacemaker |
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