| 子宫内膜异位症患者核转录因子-κB及细胞间粘附分子-1的表达 |
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| 摘 要： |
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| 关 键 词： | 核转录因子 细胞间粘附分子-1 子宫内膜异位症 免疫组织化学 |
Expressions of nuclear factor-kappaB and intercellular adhesion molecule-1 in endometriosis] |
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| Authors: | Fang Wang Yuan-li He Dong-xian Peng Mu-biao Liu |
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| Institution: | Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. wangfang1973_8@hotmail.com |
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| Abstract: | OBJECTIVE: To investigate the association of nuclear factor-kappaB (NF-kappaB) and intercellular adhesion molecule-1 (ICAM-1) with endometriosis. METHODS: Immunohistochemistry was used to examine the NF-kappaB and VEGF protein expression in 35 specimens of normal endometrium, 48 eutopic endometrium of endometriosis and 76 ectopic endometrium, and the results were analyzed statistically. RESULTS: The expressions of NF-kappaB and ICAM-1 were found mainly in the glandular epithelial cells of the three endometrium specimens, with the ectopic endometriotic tissues showing the highest and normal endometrium the lowest expressions (P<0.001). NF-kappaB and ICAM-1 expressions were positively correlated to normal, eutopic and ectopic endometrium (r=0.688, 0.773 and 0.777, respectively, P<0.01). CONCLUSION: NF-kappaB and ICAM-1 may participate in the process of the pathogenesis in endometriosis. |
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