Genomic Epidemiology and Evolution of Duck Hepatitis A Virus |
| |
| Authors: | Enikő Fehé r,Szilvia Jakab,Krisztina Bali,Eszter Kaszab,Borbá la Nagy,Katalin Ihá sz,Á dá m Bá lint,Vilmos Palya,Krisztiá n Bá nyai |
| |
| Affiliation: | 1.Veterinary Medical Research Institute, Hungária krt 21, H-1143 Budapest, Hungary; (E.F.); (S.J.); (K.B.); (E.K.); (B.N.); (K.I.);2.Veterinary Diagnostic Directorate, National Food Chain Safety Office, Tábornok utca 2, H-1143 Budapest, Hungary;3.Ceva-Phylaxia Veterinary Biologicals Co., Ltd., H-1107 Budapest, Hungary;4.Department of Pharmacology and Toxicology, University of Veterinary Medicine, István utca 2, H-1078 Budapest, Hungary |
| |
| Abstract: | ![]()
Duck hepatitis A virus (DHAV), an avian picornavirus, causes high-mortality acute disease in ducklings. Among the three serotypes, DHAV-1 is globally distributed, whereas DHAV-2 and DHAV-3 serotypes are chiefly restricted to Southeast Asia. In this study, we analyzed the genomic evolution of DHAV-1 strains using extant GenBank records and genomic sequences of 10 DHAV-1 strains originating from a large disease outbreak in 2004–2005, in Hungary. Recombination analysis revealed intragenotype recombination within DHAV-1 as well as intergenotype recombination events involving DHAV-1 and DHAV-3 strains. The intergenotype recombination occurred in the VP0 region. Diversifying selection seems to act at sites of certain genomic regions. Calculations estimated slightly lower rates of evolution of DHAV-1 (mean rates for individual protein coding regions, 5.6286 × 10−4 to 1.1147 × 10−3 substitutions per site per year) compared to other picornaviruses. The observed evolutionary mechanisms indicate that whole-genome-based analysis of DHAV strains is needed to better understand the emergence of novel strains and their geographical dispersal. |
| |
| Keywords: | duck hepatitis A virus recombination Hungary |
|
|
