| 二氢埃托啡对大鼠脑阿片受体的结合特性 |
| |
| 引用本文： | 王丹心,黄矛.二氢埃托啡对大鼠脑阿片受体的结合特性[J].中国药理学与毒理学杂志,1991,5(3):161-163. |
| |
| 作者姓名： | 王丹心 黄矛 |
| |
| 作者单位： | 军事医学科学院毒物药物研究所，军事医学科学院毒物药物研究所，军事医学科学院毒物药物研究所 北京 100850，北京 100850，北京 100850 |
| |
| 摘 要： | 本文在大鼠脑匀浆P_2膜上,观察了二氢埃托啡(DHE)对~3H]纳洛酮,~3H]DPDPE和~3H]埃托啡(预先用30nmol/L吗啡和100nmol/L DADLE阻断μ和δ受体)与阿片受体结合的抑制强度。结果表明:DHE对~3H]纳洛酮与阿片受体结合的抑制强度远远大于对~3H]DPDPE和~3H]埃托啡(预先阻断μ和δ受体后)。DHE对μ,δ和κ受体的相对亲和力之比为1951:2:1,提示DHE为μ受体相对选择性配体。
|
| 关 键 词： | 二氲埃托啡 [~3H]洛酮 [~3H](D-Pen~(2 5))-脑啡肽 [~3]埃托啡 μ-阿片受体 δ-阿片受体 K-阿片受体 大鼠脑匀浆 |
Binding characteristics of dihydroetorphine to opioid receptors in rat brain |
| |
| WANG Dan-Xin,HUANG Mao,QIN Bo-Yi Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing.Binding characteristics of dihydroetorphine to opioid receptors in rat brain[J].Chinese Journal of Pharmacology and Toxicology,1991,5(3):161-163. |
| |
| Authors: | WANG Dan-Xin HUANG Mao QIN Bo-Yi Institute of Pharmacology and Toxicology Academy of Military Medical Sciences Beijing |
| |
| Institution: | WANG Dan-Xin,HUANG Mao,QIN Bo-Yi Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850 |
| |
| Abstract: | The inhibitory potency of dihydroe torphine against the binding of 3H]naloxone, 3H]DPDPE and 3H]etorphine (with mu and delta sites having been previously suppressed by 30 nmol / L morphine and 100 nmol / L DADLE) to homogenates of rat brain opioid receptors was studied. The results showed that the inhibitory potency of dihydroetorphine against the binding of 3H]naloxone was much greater than that of 3H]DPDPE and3H]etorphine. The relative affinity of dihydroetorphine to mu, delta and kappa receptors was 1951 : 2:1. This indicates that dihydroetorphine is a relative mu-receptor selective ligand. |
| |
| Keywords: | dihydroetorphine [3H]naloxone [3H](D-Pen2 5)-enkephalin [3H]etorphine mu-opioid receptor delta-opioid receptor kappa-opioid receptor rat brain homogenates |
| 本文献已被 CNKI 维普 等数据库收录！ |
